GPAT 2019 QUESTION
PAPER WITH ANSWER
Section 1&2:- Other
and Pharmaceutical chemistry
NATIONAL TESTING AGENCY (NTA) has conduct computer based Graduate
Pharmacy Aptitude Test 2019 (GPAT - 2019) on Monday, January 28, 2019 from 2.30
p.m. to 5.30 p.m. for admission to M. Pharma or its equivalent courses across the
country. as you know in this year NTA has diveded question paper in five different sections. Section wise question and answer are given below here you can find only two section's question i.e. pharmaceutical chemistry section and other section.
Q.1 Which of the
following is considered as differentiated product?
(A) Zantac
(B) Paracetamol
(C) Isoniazid
(D) Ranitidine
Q.2 Consumer who are loyal to two- three brands are considered
as:
(A) Shifting loyals
(B) Semi-core loyals
(C) Switcher loyals
(D) Split loyals
Q.3 In Direct, contact or
jet condensers, barometric leg serves one of the following functions:
(A) To remove the condensate/ cooling water mixture
(B) To measure the
pressure difference across the tube
(C) To heat the
liquid feed to its boiling point
(D) To transfer the
feed in to the evaporating chamber
Q.4 Choose the CORRECT
statement with respect to the pharmacy act, 1948:
(A) Education regulation 1991 does not
prescribe the minimum qualification for
the registration as Pharmacist
(B) State govt. is authorized to make any
rules with respect to course of study.
(C) Section 12 of the act deals with the
approval of course of study under chapter 12
thereof.
(D) Section 12 of the act deals with the approval of course
of study and examination under chapter 12 thereof.
Q.5 Penalty for the cultivation of any cannabis plant to
produce, sell, purchase transport in
contravention of Narcotic Drug and Psychotic
substance Act and Rules on first conviction is:
(A) Rigrous imprisonment up to 10 year or fine up to Rs. 1
Lakh
(B) Rigrous
imprisonment up to 10 year or fine up to Rs. 10 Lakh
(C)
Rigrous imprisonment up to 6 months
(D) fine up to Rs. 10
Lakh
Q.6 The relation between
emissive power of the surface and its absorptivity is given by :
(A) Stefan- Boltzmann
law
(B) Darcy’s Law
(C) Kirchhoff’s Law
(D) Fourier’s Law
Q.7 ELISA is based upon:
(A) Lectin- antibody
Interaction
(B) Antigen- Protein
Interaction
(C) Antigen- Antibody interaction
(D) Antibody protein
interaction
Q.8 For protein detection
most commonly used probe is:
(A) Antibody
(B) Lectin
(C) Interferon
(D) Antigen
Q.9 Hardinge mill is a variant of:
(A) Hammer mill
(B) Ball mill
(C) Rotary cutter mill
(D) fluid energy mill
Q.10 As per the MTP Act
and rules, the safe custody of ‘’form’’ is with:
(A) Owner of the approved place
(B) Registered medical practitioner
(C) Standing committee
(D) Chief Medical Officer
Q. 11 In india the patent
office at Kolkata and branch office at:
(A) Dibrugarh, Indore and vapi
(B) Chandigarh, Hyderabad and Goa
(C) Mumbai, Chennai and Delhi
(D) Kashmir, Ahmedabad and Trivandrum
Q.12 predict the λmax for π- π* absorption
band in the UV spectrum of the following compound:
(A) 240nm
(B) 241nm
(C) 237nm
(D) 215nm
Q.13 One of the following
is a most commonly used protecting group for the amines:
(A) Methoxy methyl
(MOM)
(B) Tetra hydro
pyranyl oxy (THP)
(C) Para methoxy
benzyl (PMB)
(D) t-BUTYLOXY carbonyl (t-BOC)
Q.14 Which of the following second generation β2 blockers contains 1,3,5,-
thiadiazole ring in its structure
(A) Sotalol
(B) Timolol
(C) Pindolol
(D) Penbutolol
Q.15 Retention
hyperbilirubenamia is caused due to____________
(A) Non clearance of bilirubin
(B) Choleric jaundice
(C) Reflux of bilirubin in blood stream
(D) Over production of bilirubin
Q.16 The structural
features present in anti cancer antibiotics (Doxorubicin, Daunorubicin,
Idarubicin and Epirubicin) are _____-
(A) Naphtalene nucleus connected with
amino sugar via glycosidic linkage
(B) Quinoline nucleus connected with amino
sugar via glycosidic linkage
(C) Anthracene nucleus fused to cyclo hexane ring is
subsequently connected with amino
sugar via glycosidic linkage
(D) Phenanthrene nucleus fused to cyclo
hexane ring is subsequently connected with amino
sugar via glycosidic linkage
Q.17 When 50 ml of sodium hydroxide (0.1M) is added to 100 ml of
0.1M acetic acid, pH of resultant solution is _______________(Ka of
acetic acid= 182×10-5)
(A) 8.58
(B) 7.42
(C) 7.06
(D) 4.74
Q.18 The IR absorption
peak of Nujole is due to vibration involving:
(A) O-Hstr
and O-Hdef
(B) N-Hstr
and N-H def
(C) S-Hstr
and S-Hdef
(D) C-Hstr and C-Hdef
Q.19 Von Gierke’s glycogen
storage disease is due to defect of which enzymes
(A) Phoaphofructokinase
(B) Glucosyl 4-6
transferase
(C) Glucose -6- phosphate
(D) Glycogen phosphorylase
Q.20 The basic ring
present in the antihypertensive and antiglaucoma drug “Timolol” is:
(A) 1,3,5 -Thiadiazole and Morpholine
(B) 1,2,4- Thiadiazole and Morpholine
(C) 1,3- Thiazole and Morpholine
(D) 1,2,5- Thiadiazole and Morpholine
Q.21 Anti addition of bromine to trans-2-butene yield:
(A) Eantiomer and racemic mixture
(B) Only meso compound
(C) Only enantiomer
(D) Only racemic mixture
Q.22 pM indicators used in :
(A) Complexometric titration
(B) Acid- base titration
(C) Redox titration
(D) Non- Aqueous titration
Q.23 Identify the name reaction-
(A) Wolf-Kishner reduction
(B) Curtius
Rearrangement
(C) Clemmensen
reduction
(D) Wolf-Rearrangement
Q.24 Dehydration of this
dicarboxylic acid to obtain corresponding anhydride is difficult due to
stereochemical rearrengement
(A) Succinic acid
(B) Fumaric acid
(C) Malic acid
(D) Glutamic acid
Q.25 Oxazole is prepared by the condensation of α-amino
carbonyl compound with:
(A) Amino acid
(B) Aminoether
(C) Isocynide
(D) Iminoester
Q.26 conversion of aryldiazonium chloride can be achieved in the
presence of:
(A) Copper (I) chloride
(B) Copper (II)
chloride
(C) Calcium chloride
(D) Sodium chloride
Q.27 Identify the name of drug with the following
structure :
(A) Bisaprolol
(B) Betaxolol
(C) Esmolol
(D) Metoprolol
Q.28 Select the correct order of ortho/para directing ability of
the functional group from those given below: (Stongest first, Weakest last)
(A) –NHCOR>NR2>C6H5>I
(B) NHCOR>-NH2> C6H5>I
(C) NHCOR>-OH>-C6H5>I
(D) –NHR>-NHCOR>-C6H5>I
Q.29 Which of the following pair of drugs is considered as
selective α1-Blockers?
(A) Prazocin and Terazocin
(B) Yohimbine and Carynanthine
(C) Timolol and Metoprolol
(D) Formterol and Levalbuterol
Q.30 The following ACE
inhibitor used in treating cardiovascular disorder synthesized from the natural
amino acids L-alanine and L-proline
(A) Ramipril
(B) Captopril
(C) Lisinopril
(D) Enalapril
Q.31 The chief product obtain by the reaction of neo-pentyl
bromide under E1 reaction
condition :
(A) 2-methyl butene
(B) neo pentyl
alcohol
(C) 2-methyl-2-butene
(D) 2-methyl-1,3-butadiene
Q.32 Gabriel ring closure
method is employed for synthesis of :
(A) Oxirane
(B) 1,4-oxazine
(C) Oxaziridine
(D) Aziridine
Q.33 RNA molecules having
intrinsic catalytic activity are called as_________
(A) sn RNAs
(B) rRNAs
(C) Ribozymes
(D) mRNAs
Q.34 Choose the correct
sequence of process during Atomization in atomic absorption spectrometry :
(A) Desolvation →
Nebulization
→Dissociation→
Volatization→
Ionization
(B) Nebulization
→ Volatization →
Desolvation→
Dissociation→
Ionization
(C) Nebulization→
Desolvation →
Volatization→
Dissociation→
Ionization→
(D) Desolvation →
Nebulization →
Volatization →
Dissociation→
Ionization
Q.35 Amylopectin, a component of starch gives_________colour with
iodine
(A) No colour
(B) Green
(C) Red-purple
(D) Blue
Q.36 The following combination of drug used in treating severe travelers
diarrhea :
(A) Pyrimethamine and
sulfadiazine
(B) Trimethoprim and sulfamethoxazole
(C) Pyrimethamine and
sulfamethoxazole
(D) Trimethoprim and
sulfadiazine
Q.37 Reaction of an α-halo ester with an aldehyde or
ketone in the presence of a base like NaNH2 gives α,β-epoxy carboxylic esters. This
reaction is reffered as :
(A) Willgerodt
rearrangement
(B) Darzen’s glycidic synthesis
(C) Bamford steven
reaction
(D) Bayer villager rearrangement
Q.38 Phase solubility
Analysis curve is not a good tool for :
(A) Complex
formation
(B) Impurity
detection
(C) Polymorph
detection
(D) Bioavailability determination
Q.39 What will be the heat of vaporization of 1 mole of water,
when it has the entropy change (∆S)
of 35.2 cal/mol.deg (at 250C) ?
(A) 8465
cal/mol
(B) 10489 cal/mol
(C) 880
cal/mole
(D) 1.408
cal/mole
Q.40 Which among the following gases has the highest thermal
conductivity ?
(A) Compressed
air
(B) Oxygen
(C) Helium
(D) Nitrogen
Q.41 Blockade in β-oxidation
results in :
(A) Von Gierk’s disease
(B) Sudden infant death syndrome
(C) Scurvy
(D) Tarui’s disease
Q.42 Identify the molecule which will not exhibit Dipole moment ?
(A) Carbon
monoxide
(B) Chloroform
(C) Carbon dioxide
(D)
Ammonia
Q.43 Conversion of a carbonyl functionality directly to its
hydrocarbon in basic media can be achieved by :
(A) Wolf- Kishner reduction
(B) Clemmensen
reduction
(C) Lithium
aluminium hydride reduction
(D) Sodium
borohydride reduction
Q.44 Calculate the accurate osmotic pressure at 00C of
a blood serum sample using lewis equation having freezing point -0.530C
(A) 0.636 atm
(B) 574.28
atm
(C) 6.39
atm
(D) 0.0441
atm
Q.45 This semisynthetic derivative of penicillin is synthesized
by acylation of 6-APA with p-hydroxy phenyl glycine :
(A) Ampicillin
(B) Amoxycillin
(C) Bacampicillin
(D) Carbenicillin
Q.45 Which of the following inactive clotting factor is activated
by vitamin-K as a co-enzyme ?
(A) 2,7,9,10
(B) 2,5,9,10
(C) 2,5,6,8
(D) 1,2,3,4
Q.46 Chose the correct product for the following reaction : HNO3
+ 2H2SO4
(A) H2O
+ 2HSOᶱ4
+ NO+2
(B) H3O+
+ 2HSO+4 + NO+2
(C) OHᶱ +
2HSO4ᶱ
+ NO2ᶱ
(D) H3O+ + 2HSOᶱ4 + NO+2
Q.47 Permitted tolerance for a 100 ml class B volumetric flask
and 1000 ml class B volumetric flask according to BS 1972 specifications
respectively are _______________ml.
(A) 0.15 and 0.80
(B) 1.00
and 10.00
(C) 0.80
and 0.30
(D) 0.15
and 1.5
Q.48 Kinetically x/a(a-x)= kt is
the expression for :
(A) fractional
order reaction
(B) Pseudo
first order reaction
(C) first
order reaction
(D) Second order reaction
