NTA-GPAT 2019 QUESTION PAPER WITH ANSWER

GPAT 2019 QUESTION PAPER WITH ANSWER

Section 1&2:- Other and Pharmaceutical chemistry

NATIONAL TESTING AGENCY (NTA) has conduct computer based Graduate Pharmacy Aptitude Test 2019 (GPAT - 2019) on Monday, January 28, 2019 from 2.30 p.m. to 5.30 p.m. for admission to M. Pharma or its equivalent courses across the country. as you know in this year NTA has diveded question paper in five different sections. Section wise question and answer are given below here you can find only two section's question i.e. pharmaceutical chemistry section and other section. 

Q.1  Which of the following is considered as differentiated product?

                (A) Zantac

                (B) Paracetamol

                (C) Isoniazid

                (D) Ranitidine

Q.2 Consumer who are loyal to two- three brands are considered as:

                (A) Shifting loyals

                (B) Semi-core loyals

                (C) Switcher loyals

                (D) Split loyals

Q.3  In Direct, contact or jet condensers, barometric leg serves one of the following functions:

                (A) To remove the condensate/ cooling water mixture

                (B) To measure the pressure difference across the tube

                (C) To heat the liquid feed to its boiling point

                (D) To transfer the feed in to the evaporating chamber

Q.4  Choose the CORRECT statement with respect to the pharmacy act, 1948:

                (A) Education regulation 1991 does not prescribe the minimum qualification for 

                       the  registration as Pharmacist

                (B) State govt. is authorized to make any rules with respect to course of study.

                (C) Section 12 of the act deals with the approval of course of study under chapter 12 

                      thereof.

                (D) Section 12 of the act deals with the approval of course of study and examination                          under chapter 12 thereof.

Q.5 Penalty for the cultivation of any cannabis plant to produce, sell, purchase transport in

 contravention of Narcotic Drug and Psychotic substance Act and Rules on first conviction is:

                (A) Rigrous imprisonment up to 10 year or fine up to Rs. 1 Lakh

                (B) Rigrous imprisonment up to 10 year or fine up to Rs. 10 Lakh

                (C) Rigrous imprisonment up to 6 months             

                (D) fine up to Rs. 10 Lakh

Q.6  The relation between emissive power of the surface and its absorptivity is given by :

                (A) Stefan- Boltzmann law

                (B) Darcy’s Law

                (C) Kirchhoff’s Law

                (D) Fourier’s Law

Q.7  ELISA is based upon:

                (A) Lectin- antibody Interaction

                (B) Antigen- Protein Interaction

                (C) Antigen- Antibody interaction

                (D) Antibody protein interaction

Q.8  For protein detection most commonly used probe is: 

                (A) Antibody

                (B) Lectin

                (C) Interferon

                (D) Antigen

Q.9 Hardinge mill is a variant of: 

                (A) Hammer mill

                (B) Ball mill

                (C) Rotary cutter mill

                (D) fluid energy mill

Q.10  As per the MTP Act and rules, the safe custody of ‘’form’’ is with: 

                (A) Owner of the approved place

                (B) Registered medical practitioner

                (C) Standing committee

                (D) Chief Medical Officer

Q. 11  In india the patent office at Kolkata and branch office at:

                (A) Dibrugarh, Indore and vapi

                (B) Chandigarh, Hyderabad and Goa

                (C) Mumbai, Chennai and Delhi

                (D) Kashmir, Ahmedabad and Trivandrum

Q.12   predict the λ_max for π- π* absorption band in the UV spectrum of the following compound:

                (A) 240nm

                (B) 241nm

                (C) 237nm

                (D) 215nm

Q.13  One of the following is a most commonly used protecting group for the amines:

                (A) Methoxy methyl (MOM)

                (B) Tetra hydro pyranyl oxy (THP)

                (C) Para methoxy benzyl (PMB)

                (D) t-BUTYLOXY carbonyl (t-BOC)

Q.14 Which of the following second generation β₂ blockers contains 1,3,5,- thiadiazole ring in its structure

                (A) Sotalol

                (B) Timolol

                (C) Pindolol

                (D) Penbutolol

Q.15  Retention hyperbilirubenamia is caused due to____________

                (A) Non clearance of bilirubin

                (B) Choleric jaundice

                (C) Reflux of bilirubin in blood stream

                (D) Over production of bilirubin

Q.16  The structural features present in anti cancer antibiotics (Doxorubicin, Daunorubicin, Idarubicin and Epirubicin) are _____-

                (A) Naphtalene nucleus connected with amino sugar via glycosidic linkage

                (B) Quinoline nucleus connected with amino sugar via glycosidic linkage

                (C) Anthracene nucleus fused to cyclo hexane ring is subsequently connected with amino

                sugar via glycosidic linkage

                (D) Phenanthrene nucleus fused to cyclo hexane ring is subsequently connected with amino

 sugar via glycosidic linkage

Q.17 When 50 ml of sodium hydroxide (0.1M) is added to 100 ml of 0.1M acetic acid, p^H of resultant solution is _______________(Ka of acetic acid= 182×10^-5)

                (A) 8.58

                (B) 7.42

                (C) 7.06

                (D) 4.74

Q.18  The IR absorption peak of Nujole is due to vibration involving:

                (A) O-H_str and O-H_def

                (B) N-H_str and N-H _def

                (C) S-H_str and S-H_def

                (D) C-H_str and C-H_def

Q.19  Von Gierke’s glycogen storage disease is due to defect of which enzymes

                (A) Phoaphofructokinase

                (B) Glucosyl 4-6 transferase

                (C) Glucose -6- phosphate

                (D) Glycogen phosphorylase

Q.20  The basic ring present in the antihypertensive and antiglaucoma drug “Timolol” is: 

                (A) 1,3,5 -Thiadiazole and Morpholine

                (B) 1,2,4- Thiadiazole and Morpholine

                (C) 1,3- Thiazole and Morpholine

                (D) 1,2,5- Thiadiazole and Morpholine

Q.21 Anti addition of bromine to trans-2-butene yield:

                (A) Eantiomer and racemic mixture

                (B) Only meso compound

                (C) Only enantiomer

                (D) Only racemic mixture

Q.22 pM indicators used in : 

                (A) Complexometric titration

                (B) Acid- base titration

                (C) Redox titration

                (D) Non- Aqueous titration

Q.23 Identify the name reaction-

                (A) Wolf-Kishner reduction

                (B) Curtius Rearrangement

                (C) Clemmensen reduction

                (D) Wolf-Rearrangement

Q.24  Dehydration of this dicarboxylic acid to obtain corresponding anhydride is difficult due to stereochemical rearrengement 

                (A) Succinic acid

                (B) Fumaric acid

                (C) Malic acid

                (D) Glutamic acid

Q.25 Oxazole is prepared by the condensation of α-amino carbonyl compound with:

                (A) Amino acid

                (B) Aminoether

                (C) Isocynide

                (D) Iminoester

Q.26 conversion of aryldiazonium chloride can be achieved in the presence of:

                (A) Copper (I) chloride

                (B) Copper (II) chloride

                (C) Calcium chloride

                (D) Sodium chloride

Q.27  Identify the name of drug with the following structure :

                (A) Bisaprolol

                (B) Betaxolol

                (C) Esmolol

                (D) Metoprolol

Q.28 Select the correct order of ortho/para directing ability of the functional group from those given below: (Stongest first, Weakest last) 

                (A) –NHCOR>NR₂>C₆H₅>I

                (B) NHCOR>-NH₂> C₆H₅>I

                (C) NHCOR>-OH>-C₆H₅>I

                (D) –NHR>-NHCOR>-C₆H₅>I

Q.29 Which of the following pair of drugs is considered as selective α₁-Blockers?

                (A) Prazocin and Terazocin

                (B) Yohimbine and Carynanthine

                (C) Timolol and Metoprolol

                (D) Formterol and Levalbuterol

Q.30  The following ACE inhibitor used in treating cardiovascular disorder synthesized from the natural amino acids L-alanine and L-proline

                (A) Ramipril

                (B) Captopril

                (C) Lisinopril

                (D) Enalapril

Q.31 The chief product obtain by the reaction of neo-pentyl bromide under E₁  reaction condition :

                (A) 2-methyl butene

                (B) neo pentyl alcohol

                (C) 2-methyl-2-butene

                (D) 2-methyl-1,3-butadiene

Q.32   Gabriel ring closure method is employed for synthesis of :

                (A) Oxirane

                (B) 1,4-oxazine

                (C) Oxaziridine

                (D) Aziridine

Q.33  RNA molecules having intrinsic catalytic activity are called as_________ 

                (A) sn RNAs

                (B) rRNAs

                (C) Ribozymes

                (D) mRNAs

Q.34  Choose the correct sequence of process during Atomization in atomic absorption spectrometry :

                (A) Desolvation  → Nebulization→Dissociation→ Volatization→ Ionization

                (B) Nebulization → Volatization → Desolvation→   Dissociation→   Ionization

                (C) Nebulization→ Desolvation → Volatization→ Dissociation→ Ionization→

                (D) Desolvation → Nebulization → Volatization → Dissociation→   Ionization

Q.35 Amylopectin, a component of starch gives_________colour with iodine 

                (A) No colour

                (B) Green

                (C) Red-purple

                (D) Blue

Q.36 The following combination of drug used in treating severe travelers diarrhea :

                (A) Pyrimethamine and sulfadiazine

                (B) Trimethoprim and sulfamethoxazole

                (C) Pyrimethamine and sulfamethoxazole

                (D) Trimethoprim and sulfadiazine

Q.37 Reaction of an α-halo ester with an aldehyde or ketone in the presence of a base like NaNH₂ gives α,β-epoxy carboxylic esters. This reaction is reffered as :

                (A) Willgerodt rearrangement

                (B) Darzen’s glycidic synthesis

                (C) Bamford steven reaction

                (D) Bayer villager rearrangement

Q.38  Phase solubility Analysis curve is not a good tool for :

(A) Complex formation

(B) Impurity detection

(C) Polymorph detection

(D) Bioavailability determination

Q.39 What will be the heat of vaporization of 1 mole of water, when it has the entropy change  (∆S) of 35.2 cal/mol.deg (at 25⁰C) ?

(A) 8465 cal/mol

(B) 10489 cal/mol

(C) 880 cal/mole

(D) 1.408 cal/mole

Q.40 Which among the following gases has the highest thermal conductivity ?

(A) Compressed air

(B) Oxygen

(C) Helium

(D) Nitrogen

Q.41 Blockade in β-oxidation results in :

(A) Von Gierk’s disease

(B) Sudden infant death syndrome

(C) Scurvy

(D) Tarui’s disease

Q.42 Identify the molecule which will not exhibit Dipole moment ?

(A) Carbon monoxide

(B) Chloroform

(C) Carbon dioxide

(D) Ammonia

Q.43 Conversion of a carbonyl functionality directly to its hydrocarbon in basic media can be achieved by :

(A) Wolf- Kishner reduction

(B) Clemmensen reduction

(C) Lithium aluminium hydride reduction

(D) Sodium borohydride reduction

Q.44 Calculate the accurate osmotic pressure at 0⁰C of a blood serum sample using lewis equation having freezing point -0.53⁰C

(A) 0.636 atm

(B) 574.28 atm

(C) 6.39 atm

(D) 0.0441 atm

Q.45 This semisynthetic derivative of penicillin is synthesized by acylation of 6-APA with p-hydroxy phenyl glycine :

(A) Ampicillin

(B) Amoxycillin

(C) Bacampicillin

(D) Carbenicillin

Q.45 Which of the following inactive clotting factor is activated by vitamin-K as a co-enzyme ?

(A) 2,7,9,10

(B) 2,5,9,10

(C) 2,5,6,8

(D) 1,2,3,4

Q.46 Chose the correct product for the following reaction : HNO₃ + 2H₂SO₄

(A) H₂O + 2HSOᶱ₄ + NO⁺₂

(B) H₃O⁺ + 2HSO⁺₄ + NO⁺₂

(C) OHᶱ + 2HSO4ᶱ + NO₂ᶱ

(D) H₃O⁺ + 2HSOᶱ₄ + NO⁺₂

Q.47 Permitted tolerance for a 100 ml class B volumetric flask and 1000 ml class B volumetric flask according to BS 1972 specifications respectively are _______________ml.

(A) 0.15 and 0.80

(B) 1.00 and 10.00

(C) 0.80 and 0.30

(D) 0.15 and 1.5

Q.48 Kinetically x/a(a-x)= kt is the expression for :

(A) fractional order reaction

(B) Pseudo first order reaction

(C) first order reaction

(D) Second order reaction

                                                                   Pharma Discussion Forum Team is always with you

also read subject wise important topic for GPAT 2019